4-(Acetamidomethyl)benzoic acid → N-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]benzyl}acetamide
Reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH3:15][C:16]1[C:17]([N:23]2[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]2)=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=1>>[CH3:15][C:16]1[C:17]([N:23]2[CH2:24][CH2:25][N:26]([C:10]([C:9]3[CH:8]=[CH:7][C:6]([CH2:5][NH:4][C:1](=[O:3])[CH3:2])=[CH:14][CH:13]=3)=[O:12])[CH2:27][CH2:28]2)=[N:18][CH:19]=[C:20]([CH3:22])[CH:21]=1Participants
3
Procedure
Using 4-(acetylaminomethyl)benzoic acid (116 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (115 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87, the title compound (156 mg) was obtained.
Workup
- customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Example 87