4-(Acetamidomethyl)benzoic acid → N-{4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]benzyl}acetamide
Reaction equation
[C:1]([NH:4][CH2:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[CH:15]1([C:18]2[CH:19]=[C:20]([CH3:30])[C:21]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[N:22][CH:23]=2)[CH2:17][CH2:16]1>>[CH:15]1([C:18]2[CH:19]=[C:20]([CH3:30])[C:21]([N:24]3[CH2:25][CH2:26][N:27]([C:10]([C:9]4[CH:8]=[CH:7][C:6]([CH2:5][NH:4][C:1](=[O:3])[CH3:2])=[CH:14][CH:13]=4)=[O:12])[CH2:28][CH2:29]3)=[N:22][CH:23]=2)[CH2:17][CH2:16]1Participants
3
Procedure
Using 4-(acetylaminomethyl)benzoic acid (116 mg) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (156 mg) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87, the title compound (96 mg) was obtained.
Workup
- customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Example 87