4-{[(Methylsulfonyl)amino]methyl}benzoic acid → N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]benzyl}methanesulfonamide
Reaction equation
[CH3:1][S:2]([NH:5][CH2:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][CH:8]=1)(=[O:4])=[O:3].Cl.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]([CH:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1>>[CH3:17][C:18]1[CH:19]=[CH:20][C:21]([C:24]([CH:26]2[CH2:27][CH2:28][N:29]([C:11]([C:10]3[CH:9]=[CH:8][C:7]([CH2:6][NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:15][CH:14]=3)=[O:13])[CH2:30][CH2:31]2)=[O:25])=[CH:22][CH:23]=1Participants
3
Procedure
Using 4-(methanesulfonylaminomethyl)benzoic acid (145 mg) and (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (152 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (84 mg) was obtained.
Workup
- customby the reaction and treatment in the same manner as in Example 86