4-(Methylsulfonamido)benzoic acid → N-{4-[4-(4-methylbenzoyl)piperidine-1-carbonyl]phenyl}methanesulfonamide
Reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:14]=[CH:13][C:9]([C:10]([OH:12])=O)=[CH:8][CH:7]=1)(=[O:4])=[O:3].Cl.[CH3:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]([CH:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[O:24])=[CH:19][CH:18]=1>>[CH3:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]([CH:25]2[CH2:26][CH2:27][N:28]([C:10]([C:9]3[CH:8]=[CH:7][C:6]([NH:5][S:2]([CH3:1])(=[O:3])=[O:4])=[CH:14][CH:13]=3)=[O:12])[CH2:29][CH2:30]2)=[O:24])=[CH:21][CH:22]=1Participants
3
Procedure
Using 4-methanesulfonylaminobenzoic acid (136 mg) and (4-methylphenyl)(piperidin-4-yl)methanone hydrochloride (152 mg) and by the reaction and treatment in the same manner as in Example 86, the title compound (37 mg) was obtained.
Workup
- customby the reaction and treatment in the same manner as in Example 86