Boron tribromide → 4-Chloro-2-(4-hydroxyphenylamino)benzoic acid

HRID 2413274

Reaction equation

HRID 2413274 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][CH:13]=2)[CH:3]=1.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 666744-Chloro-2-((4-methoxyphenyl)amino)benzoic acid

Product 1

HCID 4254234-Chloro-2-(4-hydroxyphenylamino)benzoic acid

Procedure

4-Chloro-2-(4-hydroxyphenylamino)benzoic acid [XI; R=4Cl, R"=H, OH at 4-position] was prepared by reaction of 4-chloro-2-(4-methoxyphenylamino)benzoic acid with boron tribromide according to the procedure of Example 3, part (b), and obtained as a gray solid, m.p. 164°-165° C.

Workup

  1. customobtained as a gray solid, m.p. 164°-165° C.

Sources & evidence

ORD record
ord-480b9b5a069a44bf9376734dad3fd196
Source dataset
uspto-grants-1985_01
Patent number
US04496590

Linked notes

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