Ammonia → 2,2-Dimethyl-5-oxo-1-imidazolidineacetamide
Reaction equation
[CH3:1][C:2]1([CH3:14])[NH:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9](OCC)=[O:10].[NH3:15]>CO>[CH3:1][C:2]1([CH3:14])[NH:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]([NH2:15])=[O:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
An ice cold solution of ethyl 2,2-dimethyl-5-oxo-1-imidazolidineacetate (2 g) in methanol (150 ml) was saturated with gaseous ammonia. The solution was stirred at room temperature for 36 hours. After evaporation the residue was chromatographed on a silica gel column, eluting with dichloromethane/methanol 6:4. The selected fractions were collected, evaporated and the residue was crystallized from ethanol, to give 1 g of the title compound, as a white powder, m.p. 144°-146° C.
Workup
- customAfter evaporation the residue
- customwas chromatographed on a silica gel column
- washeluting with dichloromethane/methanol 6:4
- customThe selected fractions were collected
- customevaporated
- customthe residue was crystallized from ethanol
Sources & evidence
- ORD record
- ord-9389de9317af4ac8bd605a3fd718a821
- Source dataset
- uspto-grants-1988_01
- Patent number
- US04719222
Reaction notes
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