2-Methoxyaniline → 4-((2-Methoxyphenyl)sulfamoyl)benzoic acid

HRID 2414

Reaction equation

HRID 2414 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH2:9])=[CH:5][CH:6]=[CH:7][CH:8]=1.Cl[S:11]([C:14]1[CH:22]=[CH:21][C:17]([C:18]([OH:20])=[O:19])=[CH:16][CH:15]=1)(=[O:13])=[O:12]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][S:11]([C:14]1[CH:15]=[CH:16][C:17]([C:18]([OH:20])=[O:19])=[CH:21][CH:22]=1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 70002-MethoxyanilineHCID 823854-(Chlorosulfonyl)benzoic acid

Product 1

HCID 23335054-((2-Methoxyphenyl)sulfamoyl)benzoic acidYield 95.7%

Procedure

Using o-anisidine (0.585 ml, 5.0 mmol) and 4-(chlorosulfonyl)benzoic acid (1.15 g, 5.0 mmol), the procedure of Reference Example 2 was repeated to obtain 1.47 g (95.5%) of the title compound in the form of pink powder.

Sources & evidence

ORD record
ord-bcfcdbed56674c439cbfcd16edd11134
Source dataset
uspto-grants-1998_03
Patent number
US05728835

Linked notes

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