1-(4-Piperidinyl)-1,2-dihydro-4H-3,1-benzoxazin-2-one hydrochloride → HCID 22644609, compound
Reaction equation
Br[C:2]1[S:3][CH:4]=[C:5]([C:7]([NH:9][CH:10]([CH3:12])[CH3:11])=[O:8])[N:6]=1.Cl.[NH:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH2:23][O:22][C:21]2=[O:30])[CH2:16][CH2:15]1>>[CH3:11][CH:10]([NH:9][C:7]([C:5]1[N:6]=[C:2]([N:14]2[CH2:15][CH2:16][CH:17]([N:20]3[C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH2:23][O:22][C:21]3=[O:30])[CH2:18][CH2:19]2)[S:3][CH:4]=1)=[O:8])[CH3:12]Participants
3
Procedure
The title compound was prepared from the product of step (i) (0.16 g) and 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (0.15 g) using the method of example 115 step (ii). Yield 0.04 g.
Sources & evidence
- ORD record
- ord-3b51fe1de7854b5380ee78f4e561f0e1
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06812226B2