HCID 69448738, compound → Methyl 3-amino-4-formylbenzoate
Reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([CH2:10][OH:11])=[C:6]([NH2:12])[CH:5]=1>C(Cl)Cl.O=[Mn]=O>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([CH:10]=[O:11])=[C:6]([NH2:12])[CH:5]=1Participants
4
Reagents, catalysts & solvents 2
Procedure
Dissolve 3-amino-4-hydroxymethyl-benzoic acid methyl ester (step (c), 4.2 g, 23.3 mmol) in 125 mL of anhydrous CH2Cl2 and add MnO2 (20.2 g, 232.8 mmol) and stirred at RT. After 5 h, the solution was filtered through Celite and concentrated to afford the title compound as a yellow solid upon drying under vacuum. MS m/z: 180.1 (M+1).
Workup
- filtrationthe solution was filtered through Celite
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-c1abce607aa34c8b9de0207bd568fb73
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06822097B1
Reaction notes
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