4-(1H-Pyrazol-1-yl)benzaldehyde → (2E)-3-[4-(3-isoxazolyl)phenyl]-2-propenal

Reaction equation

[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=2)=[N:2]1.N1(C2C=C[C:22]([CH:23]=[O:24])=CC=2)C=CC=N1>>[O:1]1[CH:5]=[CH:4][C:3]([C:6]2[CH:13]=[CH:12][C:9](/[CH:10]=[CH:22]/[CH:23]=[O:24])=[CH:8][CH:7]=2)=[N:2]1

Participants

Reactant 2

HCID 27764774-(1H-Pyrazol-1-yl)benzaldehyde

HCID 226307854-(Isoxazol-3-yl)benzaldehyde

Product 1

HCID 22631261(2E)-3-[4-(3-isoxazolyl)phenyl]-2-propenal

Procedure

The title compound is prepared by a procedure analogous to Reference Example 30 by substituting 4-(3-isoxazolyl)benzaldehyde (prepared as described in Reference Example 74) for the 4-(1H-pyrazol-1-yl)-benzaldehyde of Reference Example 30. MS 200 (M+H)+.

Sources & evidence

ORD record: ord-ada4f44fd0f248d1b40af23a1ccc187f
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06825170B2

Reaction notes

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