HCID 10104631, compound → Ammonia
Reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1>[Pd].C(O)C>[NH3:3].[N:3]1[CH:2]=[CH:7][CH:6]=[C:5]([N:8]2[CH2:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[N:4]=1Participants
5
Reactant 1
Product 2
Reagents, catalysts & solvents 2
Procedure
A mixture of 1-(3-Chloro-6-pyridazinyl)-homopiperazine (5.56 g, 26.1 mmol), palladium on carbon (2.1 g, 10%) and ethanol (150 ml) was stirred under hydrogen overnight. The crude product was filtered through celite and evaporated. Chromatography on silica gel with dichloromethane, methanol and conc. ammonia (89:10:1) gave the title compound as free base. Yield 2.78 g, 60%, 185.0-186.9° C.
Workup
- filtrationThe crude product was filtered through celite
- customevaporated
Sources & evidence
- ORD record
- ord-bc396a0d75ab4e1080bd8990b332a58c
- Source dataset
- uspto-grants-2004_11
- Patent number
- US06825189B1
Reaction notes
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