2-Aminopyridine → 3-methoxy-N-pyridin-2-ylbenzamide

HRID 2419

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[C:8](Cl)(=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1>>[CH3:16][O:15][C:11]1[CH:10]=[C:9]([CH:14]=[CH:13][CH:12]=1)[C:8]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:17]

Participants

Reactant 2

HCID 104392-Aminopyridine

HCID 74374m-Anisoyl chloride

Product 1

HCID 7755683-methoxy-N-pyridin-2-ylbenzamideYield 21%

Procedure

Using 2-aminopyridine (670 mg, 7.12 mmol) and m-anisoyl chloride (1.2 ml, 8.55 mmol), the procedure of Reference Example 13 was repeated to obtain 341 mg (21.0%) of the title compound in the form of light yellow oil.

Sources & evidence

ORD record: ord-73cffb0515534384845ebf7bb0293e1c
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05728835

Linked notes

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