1-Acetamido-3-(4'-fluoro-4-biphenylyl)-butane → 3-(4'-Fluoro-4-biphenylyl)butylamine
Reaction equation
C([NH:4][CH2:5][CH2:6][CH:7]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1)[CH3:8])(=O)C>[OH-].[K+]>[F:21][C:18]1[CH:17]=[CH:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([CH:7]([CH3:8])[CH2:6][CH2:5][NH2:4])=[CH:10][CH:11]=2)=[CH:20][CH:19]=1Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 28.5 g of 1-acetamido-3-(4'-fluoro-4-biphenylyl)-butane in 800 ml of 10% methanolic KOH solution is boiled for 48 hours. The solution is concentrated and worked up using water and ether to give 3-(4'-fluoro-4-biphenylyl)-butylamine; hydrochloride, m.p. 222° - 224°.
Workup
- concentrationThe solution is concentrated
Sources & evidence
- ORD record
- ord-a471968d826c439f961a6074a8a2cde7
- Source dataset
- uspto-grants-1978_08
- Patent number
- US04110447
Reaction notes
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