tert-Butanol → 3-(2-Tert-butoxy-2-oxoethoxy)-4-chlorobenzoic acid
Reaction equation
[C:1]([O:5][C:6](=[O:20])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:12]([O:14]C)=[O:13])([CH3:4])([CH3:3])[CH3:2].C(O)(C)(C)C>O>[C:1]([O:5][C:6](=[O:20])[CH2:7][O:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=1[Cl:19])[C:12]([OH:14])=[O:13])([CH3:4])([CH3:2])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Methyl 3-(2-tert-butoxy-2-oxoethoxy)-4-chlorobenzoate (0.7 g) in 9:1 tert butanol:water was subjected to Antarctica B lipase for 6 d. Filtration and evaporation of the solvent yielded the subtitle compound as an off-white solid (0.6 g).
Workup
- filtrationFiltration and evaporation of the solvent
Sources & evidence
- ORD record
- ord-2a4a984cb75f44cda1ee1431d3326581
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07956070B2
Reaction notes
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