Ammonia → 2-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-8-methoxyquinazolin-4(3H)-one

HRID 2422596Notes

Reaction equation

HRID 2422596 reaction equation
[NH2:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[NH3:13].[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([CH:29]=O)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1>>[CH:14]1([N:18]2[CH2:23][CH2:22][CH:21]([O:24][C:25]3[CH:32]=[CH:31][C:28]([C:29]4[NH:13][C:4](=[O:6])[C:3]5[C:2](=[C:10]([O:11][CH3:12])[CH:9]=[CH:8][CH:7]=5)[N:1]=4)=[CH:27][CH:26]=3)[CH2:20][CH2:19]2)[CH2:17][CH2:16][CH2:15]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 2557202-Amino-3-methoxybenzoic acidHCID 866244614-[(1-Cyclobutyl-4-piperidinyl)oxy]benzaldehyde

Product 1

HCID 1361882992-{4-[(1-cyclobutylpiperidin-4-yl)oxy]phenyl}-8-methoxyquinazolin-4(3H)-one

Procedure

The entitled compound was obtained according to the method of Example 15 but starting from 2-amino-3-methoxybenzoic acid, ammonia and 4-[(1-cyclobutyl-4-piperidinyl)oxy]benzaldehyde.

Workup

  1. customThe entitled compound was obtained

Sources & evidence

ORD record
ord-b796356a2a9a470f84f5ad055e8a29ec
Source dataset
uspto-grants-2011_06
Patent number
US07960394B2

Reaction notes

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