Thionyl Chloride → 2-Chloro-2-oxoethyl 4'-chlorobiphenyl-4-sulfonate

HRID 2422925

Reaction equation

HRID 2422925 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([O:17][CH2:18][C:19]([OH:21])=O)(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.S(Cl)([Cl:24])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([O:17][CH2:18][C:19]([Cl:24])=[O:21])(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 86628700HCID 86628700, compound

Product 1

HCID 866287022-Chloro-2-oxoethyl 4'-chlorobiphenyl-4-sulfonate

Procedure

A mixture of acid 13 (100 mg, 0.306 mmol) and thionyl chloride (1 ml) was heated at reflux for 1.5 h. The excess thionyl chloride was removed in vacuo and the resulting pale yellow/white solid dried under high vacuum at 50° C. for 1.5 h. The product acid chloride 14 was used without further purification.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1.5 h
  3. customThe excess thionyl chloride was removed in vacuo
  4. customthe resulting pale yellow/white solid dried under high vacuum at 50° C. for 1.5 h
  5. customThe product acid chloride 14 was used without further purification

Sources & evidence

ORD record
ord-d8e1d267abee4aeba70658dc436a7c38
Source dataset
uspto-grants-2011_06
Patent number
US07960434B2

Linked notes

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