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Tetracaine Hydrochloride → HCID 86603141, compound

HRID 2424240
Notes
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Reaction equation

HRID 2424240 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[O:13])=[CH:10][CH:11]=1.Cl.[C@@H:21]1([O:52][P:53]([OH:56])([OH:55])=[O:54])[C@@H:26]([O:27][P:28]([OH:31])([OH:30])=[O:29])[C@H:25]([O:32][P:33]([OH:36])([OH:35])=[O:34])[C@@H:24]([O:37][P:38]([OH:41])([OH:40])=[O:39])[C@@H:23]([O:42][P:43]([OH:46])([OH:45])=[O:44])[C@H:22]1[O:47][P:48]([OH:51])([OH:50])=[O:49]>O>[CH3:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[O:13])=[CH:8][CH:7]=1.[CH:23]1([O:42][P:43]([OH:46])([OH:45])=[O:44])[CH:24]([O:37][P:38]([OH:40])([OH:41])=[O:39])[CH:25]([O:32][P:33]([OH:35])([OH:36])=[O:34])[CH:26]([O:27][P:28]([OH:31])([OH:30])=[O:29])[CH:21]([O:52][P:53]([OH:56])([OH:55])=[O:54])[CH:22]1[O:47][P:48]([OH:50])([OH:51])=[O:49]
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

4

Reactant 2

HCID 8695Tetracaine HydrochlorideHCID 178527091HCID 178527091, compound

Product 1

HCID 86603141HCID 86603141, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1.0 g tetracaine hydrochloride (3.33 mmol) was dissolved in 40 mL water and with vigorous stirring, 20.5 mL of the phytic acid solution of Example 1 was added. After another 30 min of stirring, the precipitate was centrifuged and washed with water. The final products were in the form of white powder. The solubility of the complex in different buffers is shown below.

Workup

  1. additionwas added
  2. washwashed with water

Sources & evidence

ORD record
ord-7a49498374744f4db68eab7c6e267cb7
Source dataset
uspto-grants-2011_06
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07964219B2

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes