4-Fluorobiphenyl → 4'-Fluorobiphenyl sulfonic acid

HRID 2425129Notes

Reaction equation

HRID 2425129 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 94614-FluorobiphenylHCID 24638Chlorosulfonic acid

Product 1

HCID 181795134'-Fluorobiphenyl sulfonic acid

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

4′-Fluorobiphenyl (5 g) was dissolved in chloroform (100 mL) at room temperature. Chlorosulfonic acid (5 g) was added dropwise and stirring was continued for a further 4 hours, after which the solvent was allowed to slowly evaporate until precipitation was seen. The mixture was left to recrystallised overnight and the solid was collected by filtration. Further crops of crystals were collected from the filtrate.

Workup

  1. customto slowly evaporate until precipitation
  2. waitThe mixture was left
  3. customto recrystallised overnight
  4. filtrationthe solid was collected by filtration
  5. customFurther crops of crystals were collected from the filtrate

Sources & evidence

ORD record
ord-cac7a01dc1c048cab8ea26a96b5eb42f
Source dataset
uspto-grants-2011_06
Patent number
US07964643B2

Reaction notes

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