Benzhydrylamine → N-(diphenylmethyl)-2-[(4-fluorophenyl)formamido]acetamide

Reaction equation

[F:1][C:2]1[CH:14]=[CH:13][C:5]([C:6](=[O:12])[NH:7][CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[C:15]1([CH:21]([NH2:28])[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH:21]([NH:28][C:9]([CH2:8][NH:7][C:6](=[O:12])[C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:14][CH:13]=1)=[O:11])([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

Reactant 2

HCID 7036Benzhydrylamine

HCID 6993414-Fluorohippuric acid

Product 1

HCID 18104758N-(diphenylmethyl)-2-[(4-fluorophenyl)formamido]acetamide

Procedure

Prepared in analogy to example 1.1 from p-fluoro-hippuric acid (CA [366-79-0]) and C,C-diphenylmethylamine.

Sources & evidence

ORD record: ord-fb2ac28a5c45422cbc10f814c2dc59e2
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07964645B2

Reaction notes

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