N-(2-cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide → 2-(4-{(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-[4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-dihydro-imidazole-1-carbonyl}-piperazin-1-yl)-N-(2-cyano-ethyl)-N-methyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	N-(2-cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide	HCID 28881147	—
Reactant	(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-[4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86602327	—
Product	2-(4-{(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-[4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-dihydro-imidazole-1-carbonyl}-piperazin-1-yl)-N-(2-cyano-ethyl)-N-methyl-acetamide	HCID 11607281	—

Reaction Steps

2-(4-{(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-[4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-dihydro-imidazole-1-carbonyl}-piperazin-1-yl)-N-(2-cyano-ethyl)-N-methyl-acetamide was prepared from (4S,5R)-4,5-bis-(4-chloro-phenyl)-2-[4-(cyano-dimethyl-methyl)-2-ethoxy-phenyl]-4,5-dihydro-imidazole-1-carbonyl chloride (example 12j) and N-(2-cyano-ethyl)-N-methyl-2-piperazin-1-yl-acetamide (example 16d) in an analogous manner as described in example 25. LR-MS: 714.3 [(M+H)+]

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07964724B2
Source dataset	uspto-grants-2011_06
ORD ID	ord-76ccd50107f34cf1b2cf9a8f681fe260
Source note	uspto-grants-2011_06