Chloroform methanol → 6-Amino-2-(2,3-dihydro-5-benzofuryl)-quinazoline

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:20]=[CH:19][C:15]3[O:16][CH2:17]O[C:14]=3[CH:13]=1)[N:6]=[CH:5]2.[CH:21](Cl)(Cl)Cl.CO>>[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([C:12]1[CH:20]=[CH:19][C:15]3[O:16][CH2:17][CH2:21][C:14]=3[CH:13]=1)[N:6]=[CH:5]2

Participants

Reactant 2

HCID 21584188Chloroform methanol

HCID 441404276-Amino-2-(3,4-methylendioxy-phenyl)quinazoline

Product 1

HCID 578631616-Amino-2-(2,3-dihydro-5-benzofuryl)-quinazolineYield 73%

Procedure

This compound was synthesized in 73% yield, according to the procedure described in example 1 for the synthesis of 6-amino-2-(1,3-benzodioxol-5-yl)-quinazoline. C16H13N3O, MW: 263.30. TLC(CHCl3/MeOH 9/1) Rf=0.65.

Workup

customThis compound was synthesized in 73% yield

Sources & evidence

ORD record: ord-9712f0b5db3c4c76a48ec439b27b2f9b
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968558B2

Reaction notes

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