Sodium borohydride → 4′-Chloro-2′-methyl[1,1′-biphenyl]-3-methanol
Reaction equation
[BH4-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH:16]=[O:17])[CH:11]=2)=[C:6]([CH3:18])[CH:5]=1>C(O)C>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([CH2:16][OH:17])[CH:11]=2)=[C:6]([CH3:18])[CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
In an atmosphere of nitrogen, under ice-cooling, sodium borohydride was added to an ethanol solution of 4′-chloro-2′-methylbiphenyl-3-carbaldehyde, followed by stirring for 1 hour to obtain (4′-chloro-2′-methylbiphenyl-3-yl)methanol.
Workup
- temperatureIn an atmosphere of nitrogen, under ice-cooling
Sources & evidence
- ORD record
- ord-5056cb66d01244229a13c6c04a5c3a0f
- Source dataset
- uspto-grants-2011_06
- Patent number
- US07968552B2
Reaction notes
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