Hydrochloric Acid → 3-[(Pyrrolidin-1-yl)methyl]benzoic acid--hydrogen chloride (1/1)

HRID 2427243

Reaction equation

C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:5]=1.[ClH:17]>>[ClH:17].[N:11]1([CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:16])=[O:2])[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 53429637Methyl 3-(pyrrolidin-1-ylmethyl)benzoate

Product 1

HCID 185258743-[(Pyrrolidin-1-yl)methyl]benzoic acid--hydrogen chloride (1/1)

Procedure

A solution of 3-pyrrolidin-1-ylmethyl-benzoic acid methyl ester (800 mg, 3.6 mmol) in aqueous 25% hydrochloric acid (15 mL) was stirred at 90° C. for 4 hours. The solvent was evaporated affording the title compound as brown oil (quantitative) that was used as such for the next step.

Workup

customThe solvent was evaporated

Sources & evidence

ORD record: ord-8cda23d7871149ac9cf399e9f52cbf07
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968583B2

Linked notes

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