Diethyl Ether → 3,5,5-Trimethyl-2-morpholinol

HRID 24275

Reaction equation

HRID 24275 reaction equation
Cl.ClC1C=C([C@@:9]2([OH:18])[O:14][CH2:13][C:12]([CH3:16])([CH3:15])[NH:11][C@@H:10]2[CH3:17])C=CC=1.C(OCC)C.[OH-].[Na+]>O>[CH3:17][CH:10]1[CH:9]([OH:18])[O:14][CH2:13][C:12]([CH3:16])([CH3:15])[NH:11]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 9943907Bupropion Morpholinol (2R,3R)-Isomer2×

Product 1

HCID 691292623,5,5-Trimethyl-2-morpholinol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

(+/−)-(2R*,3R*)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride may be converted back to its free base by the following process. A 3.0 g sample of (+/−)-(2R*,3R*)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol hydrochloride was dissolved in water (100 mL) and diethyl ether was added (200 mL). The mixture was chilled in an ice bath and the pH was adjusted to >10 with 1.0N aqueous sodium hydroxide. After stirring for 30 min., the phases were separated and the aqueous phase was extracted with diethyl ether. The combined diethyl ether extracts were dried (Na2SO4) and concentrated in vacuo to give 2.6 g of (+/−)-(2R*,3R*)-2-(3-chlophenyl)-3,5,5-trimethyl-2-morpholinol as a white solid. This was used without further purification for the chiral chromatography described below.

Workup

  1. temperatureThe mixture was chilled in an ice bath
  2. customthe phases were separated
  3. extractionthe aqueous phase was extracted with diethyl ether
  4. dry with materialThe combined diethyl ether extracts were dried (Na2SO4)
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-9864244b21134496b31878344012b8f4
Source dataset
uspto-grants-2005_02
Patent number
US06855820B2

Linked notes

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