1-Bromo-4-fluoro-2-((methoxymethoxy)methyl)benzene → HCID 11276427, compound

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([B:9]2[O:13][CH2:12][CH2:11]O2)[CH:6]=[CH:7][CH:8]=1)#[N:2].Br[C:15]1C=[CH:19][C:18]([F:21])=[CH:17][C:16]=1COCOC>>[F:21][C:18]1[CH:17]=[CH:16][C:15]2[B:9]([C:5]3[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=3)[C:1]#[N:2])[O:13][CH2:12][C:11]=2[CH:19]=1

Participants

Reactant 2

HCID 118455731-Bromo-4-fluoro-2-((methoxymethoxy)methyl)benzene

HCID 667383483-(1,3,2-Dioxaborolan-2-yl)benzonitrile

Product 1

HCID 11276427HCID 11276427, compound

Procedure

This was prepared as per the procedure in Example 11, from 2-(3-cyanophenyl)-[1,3,2]-dioxaborolane and 1-bromo-4-fluoro-2-((methoxymethoxy)methyl)benzene to afford white crystalline product.

Workup

customto afford white crystalline product

Sources & evidence

ORD record: ord-914e7de6eb6e471cb3cf55bd629d60be
Source dataset: uspto-grants-2011_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07968752B2

Reaction notes

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