5-fluoro-1,3-dihydro-2H-indol-2-one → 3-(3-Cyclopentyl-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one

HRID 24357

Reaction equation

HRID 24357 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[CH:9]=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:16][C:17]1[CH:18]=[C:19]2[C:23](=[CH:24][CH:25]=1)[NH:22][C:21](=[O:26])[CH2:20]2>>[CH:1]1([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[CH:9]=[C:20]2[C:19]3[C:23](=[CH:24][CH:25]=[C:17]([F:16])[CH:18]=3)[NH:22][C:21]2=[O:26])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 37310125-fluoro-1,3-dihydro-2H-indol-2-oneHCID 225710713-Cyclopentyl-4-methoxybenzaldehyde

Product 1

HCID 538255193-(3-Cyclopentyl-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one

Procedure

3-Cyclopentyl-4-methoxybenzaldehyde was condensed with 5-fluoro-2-oxindole to give 0.25 g of 3-(3-cyclopentyl-4-methoxybenzylidene)-5-fluoro-1,3-dihydroindol-2-one as a yellow-orange solid.

Sources & evidence

ORD record
ord-2fee7a52d75c46b581f8bde372d8b3d9
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Linked notes

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