5-Fluoro-2-iodobenzoic acid → 3-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

HRID 243827

Reaction equation

HRID 243827 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:16]C1C(I)=C(C=CC=1)C(O)=O.FC1C=CC(I)=C(C=1)C(O)=O>>[F:16][C:4]1[C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=[CH:2][CH:3]=1)[C:7]([OH:9])=[O:8]

Participants

4

Reactant 3

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 223203083-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 670865493-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 1, substituting for 3-fluoro-2-iodo-benzoic acid for 5-fluoro-2-iodo-benzoic acid in Step A. 1H NMR (400 MHz, CD3OD): 7.93 (s, 2H), 7.81 (d, J=8.3 Hz, 1H), 7.63-7.58 (m, 1H), 7.29 (td, J=8.9, 0.9 Hz, 1H).

Sources & evidence

ORD record
ord-b4f4c0497aa142bda1a41c8c74733dd7
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Linked notes

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