5-Fluoro-2-iodobenzoic acid → 5-Iodo-2-[1,2,3]triazol-2-yl-benzoic acid

HRID 243828

Reaction equation

HRID 243828 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].FC1C=CC([I:26])=C(C=1)C(O)=O>>[I:26][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

Participants

3

Reactant 2

HCID 131585835-Fluoro-2-iodobenzoic acidHCID 670869485-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 670867325-Iodo-2-[1,2,3]triazol-2-yl-benzoic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 1, substituting 2-bromo-5-iodobenzoic acid for 5-fluoro-2-iodo-benzoic acid in Step A. 1H NMR (400 MHz, CD3OD): 8.09 (d, J=2.0, 1H), 8.03-7.97 (m, 1H), 7.95-7.86 (m, 3H), 7.53 (d, J=8.4, 1H).

Sources & evidence

ORD record
ord-d9a258a52f604289a23b3b751f2da77e
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Linked notes

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