2-(3-fluorophenyl)benzoic Acid → 2-{5-[(3'-Fluorobiphenyl-2-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

HRID 243917

Reaction equation

HRID 243917 reaction equation
[CH2:1]1[CH:5]2[CH2:6][NH:7][CH2:8][CH:4]2[CH2:3][N:2]1[C:9]1[CH:18]=[N:17][C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[F:19][C:20]1[CH:21]=[C:22]([C:26]2[C:27]([C:32](O)=[O:33])=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH:23]=[CH:24][CH:25]=1>>[F:19][C:20]1[CH:21]=[C:22]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[C:32]([N:7]2[CH2:6][CH:5]3[CH2:1][N:2]([C:9]4[CH:18]=[N:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)[CH2:3][CH:4]3[CH2:8]2)=[O:33])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 27826842-(3-fluorophenyl)benzoic AcidHCID 610372812-(Hexahydro-pyrrolo[3,4-c]pyrrol-2-yl)-quinoxaline

Product 1

HCID 529170082-{5-[(3'-Fluorobiphenyl-2-yl)carbonyl]hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}quinoxaline

Procedure

The title compound was prepared in a manner analogous to Example 15 utilizing Intermediate 35 and 3′-fluoro-biphenyl-2-carboxylic acid. MS (ESI) mass calcd. for C27H23FN4O, 438.51; m/z found, 439.2 [M+H]+.

Sources & evidence

ORD record
ord-90986ee495e34d6bb62fb724269d05ff
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Linked notes

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