3-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid → HCID 67116820, compound

HRID 244015

Reaction equation

HRID 244015 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:19][CH:18]3[CH:14]([CH2:15][NH:16][CH2:17]3)[CH2:13]1)[N:6]=[CH:5]2.[F:20][C:21]1[C:22]([N:30]2[N:34]=[CH:33][CH:32]=[N:31]2)=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24](O)=[O:25]>>[F:20][C:21]1[C:22]([N:30]2[N:34]=[CH:33][CH:32]=[N:31]2)=[C:23]([C:24]([N:16]2[CH2:17][CH:18]3[CH:14]([CH2:13][N:12]([C:7]4[N:6]=[CH:5][C:4]5[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=5)[N:8]=4)[CH2:19]3)[CH2:15]2)=[O:25])[CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 670865493-Fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 699391556-Fluoro-2-(hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)quinazoline

Product 1

HCID 67116820HCID 67116820, compound

Procedure

The title compound was prepared in a manner analogous to Example 15, utilizing Intermediate 43 and 3-fluoro-2-(2H-1,2,3-triazol-2-yl)benzoic acid. MS (ESI): mass calculated for C23H19F2N7O, 447.16; m/z found 448.1 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.99 (s, 1H), 7.77 (d, J=15.8, 2H), 7.61 (dd, J=11.0, 5.5, 1H), 7.53-7.43 (m, 2H), 7.37-7.29 (m, 2H), 7.24 (s, 1H), 3.93 (d, J=9.9, 1H), 3.79 (dd, J=12.3, 7.4, 2H), 3.71-3.62 (m, 1H), 3.62 (s, 3H), 3.20 (dd, J=11.0, 5.3, 1H), 3.12-2.98 (m, 2H).

Sources & evidence

ORD record
ord-be716e9f2aae458688f3a4162f3766ba
Source dataset
uspto-grants-2014_02
Patent number
US08653263B2

Linked notes

Loading…