5-Chloro-4-methylindolin-2-one → 5-Chloro-3-(3-cyclopentyl-4-methoxybenzylidene)-4-methyl-1,3-dihydroindol-2-one

HRID 24430

Reaction equation

HRID 24430 reaction equation
[CH:1]1([C:6]2[CH:7]=[C:8]([CH:11]=[CH:12][C:13]=2[O:14][CH3:15])[CH:9]=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:16][C:17]1[C:25]([Cl:26])=[CH:24][CH:23]=[C:22]2[C:18]=1[CH2:19][C:20](=[O:27])[NH:21]2>>[Cl:26][C:25]1[C:17]([CH3:16])=[C:18]2[C:22](=[CH:23][CH:24]=1)[NH:21][C:20](=[O:27])[C:19]2=[CH:9][C:8]1[CH:11]=[CH:12][C:13]([O:14][CH3:15])=[C:6]([CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:7]=1

Participants

3

Reactant 2

HCID 103133885-Chloro-4-methylindolin-2-oneHCID 225710713-Cyclopentyl-4-methoxybenzaldehyde

Product 1

HCID 545294965-Chloro-3-(3-cyclopentyl-4-methoxybenzylidene)-4-methyl-1,3-dihydroindol-2-one

Procedure

3-Cyclopentyl-4-methoxybenzaldehyde was condensed with 4-methyl-5-chloro-2-oxindole to give 0.3 g of 5-Chloro-3-(3-cyclopentyl-4-methoxybenzylidene)-4-methyl-1,3-dihydroindol-2-one as a yellow-orange solid.

Sources & evidence

ORD record
ord-cca398c9c520446496b9bf7da9b15924
Source dataset
uspto-grants-2005_02
Patent number
US06855730B2

Linked notes

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