Sodium Hydroxide → 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylic acid

Temperature

20 °C

To a solution of ethyl 4-bromo-1,3-dimethyl-1H-pyrazole-5-carboxylate (200 mg) (for example, available from Sinova) in methanol (10 ml) was added 2M sodium hydroxide (5 ml) and the mixture stirred at 20° C. for 18 h. The mixture was concentrated in vacuo and the residue taken up in water (10 ml) and acidified to pH=5 using 2M hydrochloric acid. The mixture was extracted with ethyl acetate (20 ml) dried over sodium sulphate and evaporated to give the title compound (25 mg) as a white solid.

1. concentrationThe mixture was concentrated in vacuo
2. extractionThe mixture was extracted with ethyl acetate (20 ml)
3. dry with materialdried over sodium sulphate
4. customevaporated

ORD record

ord-892f17811ad04ed5ba0471035bfa38ca

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08658635B2