2,4-Difluoro-3-methylbenzoic acid → 2,4-Difluoro-3-methyl-5-(pyrazin-2-ylcarbonyl)benzoic acid

HRID 245384

Reaction equation

HRID 245384 reaction equation
[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CON(C)[C:16]([C:18]1[CH:23]=[N:22][CH:21]=[CH:20][N:19]=1)=[O:17]>>[F:1][C:2]1[C:10]([CH3:11])=[C:9]([F:12])[C:8]([C:16]([C:18]2[CH:23]=[N:22][CH:21]=[CH:20][N:19]=2)=[O:17])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

3

Reactant 2

HCID 139868372,4-Difluoro-3-methylbenzoic acid2×HCID 22613131N-Methoxy-N-methylpyrazine-2-carboxamide

Product 1

HCID 866580592,4-Difluoro-3-methyl-5-(pyrazin-2-ylcarbonyl)benzoic acid

Procedure

Starting materials: 2,4-difluoro-3-methylbenzoic acid (Intermediate 46) and N-methoxy-N-methylpyrazine-2-carboxamide.

Sources & evidence

ORD record
ord-ff64c0ab4dfc4913b0ea658b5a1ad0db
Source dataset
uspto-grants-2014_02
Patent number
US08658641B2

Linked notes

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