HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 246Generated: October 23, 2026
Benzylamine → 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one
https://huagongshe.com/en/reaction/246
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 6-Bromo-3,4-dihydro-2H-isoquinolin-1-one | HCID 21865450 | — |
| Reagent | Sodium Methoxide | HCID 10942334 | — |
| Catalyst | 1,2-Bis(diphenylphosphino)ethane | HCID 74267 | — |
| Catalyst | Palladium (II) acetate | HCID 4144353 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-benzylamino-3,4-dihydro-2H-isoquinolin-1-one | HCID 67223915 | 0% |
Reaction Steps
In a small MW* sealed test tube was 6-bromo-3,4-dihydroisoquinolin-1(2H)-one (50 mg, 0.22 mmol), phenylmethanamine (24.16 µl, 0.22 mmol), palladium(II) acetate (2.483 mg, 0.01 mmol), Ethylenebis(diphenylphosphine) (8.81 mg, 0.02 mmol) and sodium methoxide (13.14 mg, 0.24 mmol) in toluene (2188 µl) combined to give a orange suspension. Heated reaction to 100°C overnight. Took LCMS - No reaction, only see unreacted SM. Discarded reaction.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-08bf18171af14ad9bb3d94faf7cd7b73 |
|---|
| Source note | 750 AstraZeneca ELN dataset |
|---|
