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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24613Generated: October 23, 2026

3,3-Diphenylpropylamine → Benzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

https://huagongshe.com/en/reaction/24613

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,3-DiphenylpropylamineHCID 79698—
Reactant5-benzyl 1-(4-nitrophenyl) 6-(3-chlorophenyl)-2-methoxy-4-methyl-6H-pyrimidine-1,5-dicarboxylateHCID 69745932—
SolventAcetonitrileHCID 6342—
ProductBenzyl 4-(3-chlorophenyl)-3-(3,3-diphenylpropylcarbamoyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylateHCID 15546109—

Reaction Conditions

Temperature60 °C

Reaction Steps

10 ml of acetonitrile was added to a mixture of 200 mg (0.373 mmol) of 5-benzyl 1-(4-nitrophenyl) 6-(3-chlorophenyl)-2-methoxy-4-methyl-6H-pyrimidine-1,5-dicarboxylate and 78.9 mg (0.373 mmol) of 3,3-diphenylpropylamine, and they were stirred at 60° C. for 30 minutes. The solvent was evaporated under reduced pressure to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06855716B2
Source datasetuspto-grants-2005_02
ORD IDord-74147c16a95240d69ee024fbc23bdbd2
Source noteuspto-grants-2005_02