HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (S)-tert-butyl 1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethylcarbamate | HCID 71280415 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (S)-1-(5-(trifluoromethyl)-1H-imidazol-2-yl)ethanamine hydrochloride | HCID 71279885 | — |
Reaction Steps
A solution of [(S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethyl]-carbamic acid tert-butyl ester (50 mg, 179 μmol) in 4M HCl in dioxane (2 mL) was stirred at room temperature for 15 h. The mixture was concentrated in vacuo then triturated with ether to give (S)-1-(5-trifluoromethyl-1H-imidazol-2-yl)-ethylamine hydrochloride (35 mg, quantitative) as a yellow oil. LCMS, [M+H]=180.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08658646B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-88c914026c9440bfbb921eb358b02c00 |
| Source note | uspto-grants-2014_02 |