Thionyl Chloride → 1,2,2-Trichlorocyclopropane-1-carbonyl chloride
Reaction equation
S(Cl)([Cl:3])=O.[Cl:5][C:6]1([C:11]([OH:13])=O)[CH2:8][C:7]1([Cl:10])[Cl:9]>C1C=CC=CC=1>[Cl:5][C:6]1([C:11]([Cl:3])=[O:13])[CH2:8][C:7]1([Cl:10])[Cl:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Thionyl chloride (50 ml) was added to a solution of 1,2,2-trichlorocyclopropane carboxylic acid (47.4 grams) in 300 ml of benzene. The reaction mixture was heated to reflux temperature and stirred for approximately 20 hours. The solvents were evaporated in vacuo to provide the intermediate acid chloride derivative, 1,2,2-trichlorocyclopropane carboxylic acid chloride (43.8 grams).
Workup
- temperatureThe reaction mixture was heated
- temperatureto reflux temperature
- customThe solvents were evaporated in vacuo
Sources & evidence
- ORD record
- ord-f1e80488b731468fb8f34a1371877a1d
- Source dataset
- uspto-grants-1987_11
- Patent number
- US04704156
Reaction notes
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