Monochloramine → Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

Reaction equation

C[CH:2]1[O:7][CH:6](C)[CH2:5][N:4]([CH2:9][CH:10](O)C)[CH2:3]1.[Cl:13]N>>[ClH:13].[Cl:13][CH2:10][CH2:9][N:4]1[CH2:5][CH2:6][O:7][CH2:2][CH2:3]1

Participants

Reactant 2

HCID 25423Monochloramine

HCID 98999alpha,2,6-Trimethylmorpholin-4-ylethanol

Product 1

HCID 77210Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1)

Procedure

An amount, 398.5 grams, of 2,6-dimethyl-N-(2-hydroxypropyl) morpholine (2.3 moles) was condensed with the free chloroamine obtained from 390.5 grams N-chloroethyl morpholine hydrochloride (2.3 moles) as described above to give 325.4 grams (55.7%) of the catalyst as a pale yellow oil, bp 122°-124° C. at 0.3 mm of Hg. The structure was confirmed by elemental analysis, calc. 62.9 C, 10.6 H, 9.8 N; found 62.2 C, 10.4 H, 9.8 N.

Sources & evidence

ORD record: ord-400f9a2158ad4561af5265f73f0641f7
Source dataset: uspto-grants-1987_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04705840

Reaction notes

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