Acetic Anhydride → 1-Acetylindolin-2-one

HRID 24724

Reaction equation

HRID 24724 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[C:11](OC(=O)C)(=[O:13])[CH3:12]>>[C:11]([N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10])(=[O:13])[CH3:12]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 321710Oxindole

Product 1

HCID 3237191-Acetylindolin-2-one

Procedure

13.3 g (0.1 mol) of 2-indolinone and 30 ml of acetic anhydride are stirred for 3 hours at 170° C. After cooling, 150 ml of ice water are added, the crystalline product is suction filtered, washed with water and dried.

Workup

  1. temperatureAfter cooling
  2. filtrationfiltered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-76ea57a045934b3084c0c2d4c7aabd87
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Linked notes

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