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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 24738Generated: October 27, 2026

Ethyl 3-aminobenzoate → 3-[[(Z)-(2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]benzoic acid

https://huagongshe.com/reaction/24738

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-aminobenzoateHCID 11400—
ReactantSodium HydroxideHCID 14798—
Reactant1-Benzoyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinoneHCID 54432648—
SolventMethanolHCID 887—
Product3-[[(Z)-(2-oxo-1H-indol-3-ylidene)-phenylmethyl]amino]benzoic acidHCID 178517081—

Reaction Steps

Prepared analogously to Example 2c from 1-benzoyl-3-(1-chloro-1-phenyl-methylidene)-2-indolinone and ethyl 3-aminobenzoate and subsequent total saponification with sodium hydroxide solution in methanol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06855710B2
Source datasetuspto-grants-2005_02
ORD IDord-8601aa90fc2d48c88bd3f1cf1d90f95b
Source noteuspto-grants-2005_02