Sodium Hydroxide → 3-(1-Ethoxy-1-phenyl-methylidene)-2-indolinone

HRID 24767Notes

Reaction equation

HRID 24767 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6](=[C:13]([O:20][CH2:21][CH3:22])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:5]1=[O:23])(=O)C.[OH-].[Na+]>C(O)C.O>[CH2:21]([O:20][C:13](=[C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[NH:4][C:5]1=[O:23])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1)[CH3:22]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 542378881-Acetyl-3-(1-ethoxy-1-phenylmethylidene}-2-indolinone

Product 1

HCID 540376233-(1-Ethoxy-1-phenyl-methylidene)-2-indolinone

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

4.0 g (13.2 mmol) of 1-acetyl-3-(1-ethoxy-1-phenyl-methylidene)-2-indolinone are suspended in 50 ml of ethanol and after the addition of 10 ml of 4N sodium hydroxide solution stirred for 90 minutes at ambient temperature. The solution is diluted with 150 ml of water, the crystalline product is suction filtered, washed and dried.

Workup

  1. filtrationfiltered
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-18b3187e488642c0a3b625cd6c1e19ec
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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