N-(4-Nitrophenyl)propionamide → N-(4-Aminophenyl)propanamide
Reaction equation
[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3].[H][H]>CO.[Pd]>[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1)(=[O:4])[CH2:2][CH3:3]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
250 mg (2 mmol) of N-propionyl-4-nitroaniline are dissolved in 200 ml of methanol and combined with 0.6 g of 10% palladium/charcoal. The product is hydrogenated in a hydrogen atmosphere at 2 bar for 30 minutes. Then the catalyst is filtered off and the solvent is eliminated in vacuo.
Workup
- filtrationThen the catalyst is filtered off
Sources & evidence
- ORD record
- ord-3b91ba32e4944bce809d7a26b6f46926
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06855710B2
Reaction notes
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