6-Hydroxy-2-naphthoic acid → 1,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylate

HRID 247794

Reaction equation

HRID 247794 reaction equation
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:12]([OH:14])=[O:13])[CH:8]=2)[CH:3]=1.[F:15][C:16]([F:26])([F:25])[CH:17](O)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23]>C(Cl)Cl.S(=O)(=O)(O)O>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([C:12]([O:14][CH:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[C:16]([F:15])([F:25])[F:26])=[O:13])[CH:6]=[CH:5]2

Participants

5

Reactant 2

HCID 855576-Hydroxy-2-naphthoic acidHCID 978042-Octanol, 1,1,1-trifluoro-

Product 1

HCID 157248111,1,1-Trifluorooctan-2-YL 6-hydroxynaphthalene-2-carboxylate

Reagents, catalysts & solvents 2

HCID 1118Sulfuric AcidCatalystHCID 6344DichloromethaneSolvent

Procedure

To a solution of 2-hydroxy-6-carboxynaphthalene (1 g) and optically active 1,1,1-trifluoro-2-octanol (1.1 g) in methylene chloride (50 ml) was added a few drops of conc. sulfuric acid and the mixture was refluxed under stirring for about two days.

Workup

  1. temperaturethe mixture was refluxed

Sources & evidence

ORD record
ord-43d063be546145bd9ec5526f7bbccb38
Source dataset
uspto-grants-1993_05
Patent number
US05207947

Linked notes

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