Chloroethane → N-Methyl-N-{[1-[3-(p-fluorophenoxy)propyl]-4-piperidyl]methyl}-5-isoquinolinesulfonamide dihydrochloride

HRID 247848

Reaction equation

HRID 247848 reaction equation
[CH3:1][N:2]([CH2:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:19][CH2:18]1)[S:3]([C:6]1[C:7]2[CH:8]=[CH:9][N:10]=[CH:11][C:12]=2[CH:13]=[CH:14][CH:15]=1)(=[O:5])=[O:4].CC[Cl:36]>C(#N)C>[ClH:36].[ClH:36].[CH3:1][N:2]([CH2:16][CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][O:26][C:27]2[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=2)[CH2:19][CH2:18]1)[S:3]([C:6]1[C:7]2[CH:8]=[CH:9][N:10]=[CH:11][C:12]=2[CH:13]=[CH:14][CH:15]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 6337ChloroethaneHCID 9890945N-Methyl-N-{[1-[3-(p-fluorophenoxy)propyl]-4-piperidyl]methyl}-5-isoquinolinesulfonamide

Product 1

HCID 19764599N-Methyl-N-{[1-[3-(p-fluorophenoxy)propyl]-4-piperidyl]methyl}-5-isoquinolinesulfonamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

5.5 g of the compound obtained in stage A is taken up in 10 cm3 of acetonitrile. 7.5 cm3 of a 3.3N solution of hydrochloric ether are added to this solution. 3.1 g of a solid which corresponds to the title compound are obtained.

Sources & evidence

ORD record
ord-5e7f19ff56af4ccabb05d3f49423a133
Source dataset
uspto-grants-1993_05
Patent number
US05208243

Linked notes

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