1-Iodohexane → alpha-Methyl-6-(hexyloxy)-2-naphthaleneacetic acid
Reaction equation
I[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[OH:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]=[C:14]([CH:19]([CH3:23])[C:20]([OH:22])=[O:21])[CH:13]=[CH:12]2>>[CH3:23][CH:19]([C:14]1[CH:13]=[CH:12][C:11]2[C:16](=[CH:17][CH:18]=[C:9]([O:8][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])[CH:10]=2)[CH:15]=1)[C:20]([OH:22])=[O:21]Participants
3
Procedure
The title compound is prepared according to the method of Example 7 using 1-iodohexane and racemic 6-hydroxy-α-methyl-2-naphthaleneacetic acid. White crystals are obtained having a melting point of 88°-91° C.
Workup
- customWhite crystals are obtained
Sources & evidence
- ORD record
- ord-62f24be2a6f448e79f7642fd2c7b6fdb
- Source dataset
- uspto-grants-1993_05
- Patent number
- US05208344
Reaction notes
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