Thioglycolic Acid → 2-(2,5-Dichlorophenyl)-2-mercaptoacetic acid

HRID 248600

Reaction equation

Br[C:2]1[C:3]([Cl:9])=[C:4](Cl)[CH:5]=[CH:6][CH:7]=1.[Cl:10]C1C(Cl)=C(Cl)C=CC=1.[C:19]([OH:23])(=[O:22])[CH2:20][SH:21].[OH-].[K+]>>[Cl:9][C:3]1[CH:4]=[CH:5][C:6]([Cl:10])=[CH:7][C:2]=1[CH:20]([SH:21])[C:19]([OH:23])=[O:22]

Participants

Reactant 4

HCID 1133Thioglycolic Acid

HCID 68951,2,3-Trichlorobenzene

HCID 14797Potassium Hydroxide

HCID 420661-Bromo-2,3-dichlorobenzene

Product 1

HCID 224923292-(2,5-Dichlorophenyl)-2-mercaptoacetic acid

Procedure

Using the combinations of monobromodichlorobenzene or trichlorobenzene, thioglycolic acid, potassium hydroxide and solvent listed in Table 2, the reaction was carried out in the same manner as in Example 8 or 9 to yield 2,5-dichlorophenylthioglycolic acid. The results are given in Table 2.

Sources & evidence

ORD record: ord-635a18898f7e475884fece1683af069a
Source dataset: uspto-grants-1993_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05210291

Linked notes

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