HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dichlorobenzene → (2,5-Dichlorophenyl)(3-methylphenyl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dichlorobenzene | HCID 4685 | — |
| Reactant | 3-Methylbenzoyl chloride | HCID 74375 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Product | (2,5-Dichlorophenyl)(3-methylphenyl)methanone | HCID 18704036 | 53% |
Reaction Steps
The procedure of Example 2 was followed, using 22 ml (0.17 mol) of 3-toluoyl chloride and 60 g (0.45 mol) of aluminum chloride in 120 g (0.82 mol) of 1,4-dichlorobenzene. (The molar ratio of reactants was 2.6:4.8:1.0 (AlCl3 :Dichlorobenzene:3-Toluoyl Chloride)). Pure 2,5-dichloro-3'-methyl-benzophenone was isolated in 53% yield after the crude product was recrystallized twice from hexane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05210313 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-2624c3d956854183a95148f8c3cc395b |
| Source note | uspto-grants-1993_05 |