Pyrazine, 2-(chloromethyl)- → N-methyl-1-(pyrazin-2-yl)methanamine

HRID 249486

Reaction equation

HRID 249486 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1.Cl[C:10]1C(CCl)=CC=C(Cl)[N:11]=1>>[CH3:10][NH:11][CH2:2][C:3]1[CH:8]=[N:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 170169Pyrazine, 2-(chloromethyl)-HCID 6451791Pyridine, 2,6-dichloro-3-(chloromethyl)-

Product 1

HCID 16762521N-methyl-1-(pyrazin-2-yl)methanamine

Procedure

The reaction according to Reference Example 11 was carried out using 2-chloromethylpyrazine in lieu of 2,6-dichloro-3-pyridylmethyl chloride to give the title compound as oil.

Sources & evidence

ORD record
ord-79f3fdfc398947a1913a77d345fd7be3
Source dataset
uspto-grants-1993_05
Patent number
US05214152

Linked notes

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