5-Amino-2-chloropyridine → N-methyl-5-(trifluoromethyl)pyridin-3-amine

HRID 249495

Reaction equation

HRID 249495 reaction equation
[NH2:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.N[C:13]1C=CC(Cl)=NC=1>>[CH3:13][NH:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

3

Reactant 2

HCID 793055-Amino-2-chloropyridineHCID 140519365-(Trifluoromethyl)pyridin-3-amine

Product 1

HCID 21221268N-methyl-5-(trifluoromethyl)pyridin-3-amine

Procedure

The reaction procedure of Reference Example 24 was repeated except that 3-amino-5-trifluoromethylpyridine was used in lieu of 5-amino-2-chloropyridine to obtain the title compound as white crystals.

Workup

  1. customThe reaction procedure of Reference Example 24

Sources & evidence

ORD record
ord-75f9afeec9ca49aa8876b8be5c4b96cb
Source dataset
uspto-grants-1993_05
Patent number
US05214152

Linked notes

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