Ammonia → N-Amylurea

HRID 249753

Reaction equation

HRID 249753 reaction equation
[NH3:1].[N:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH3:9])=[C:3]=[O:4]>CO>[CH2:5]([NH:2][C:3]([NH2:1])=[O:4])[CH2:6][CH2:7][CH2:8][CH3:9]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 206036Pentane, 1-isocyanato-

Product 1

HCID 198194N-Amylurea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a 7.0 M solution of ammonia in methanol (32 mL) was dropwise added 1-isocyanatopentane (5.0 g, 0.044 mol). After the addition, the mixture was stirred at room temperature for 1 h and concentrated under reduced pressure to give a white solid, which was directly used for next step without further purification. LCMS calculated for C6H15N2O (M+H): 131.1. found 131.1.

Workup

  1. additionAfter the addition
  2. concentrationconcentrated under reduced pressure
  3. customto give a white solid, which
  4. customwas directly used for next step without further purification

Sources & evidence

ORD record
ord-448703fb7e8b4348bda9d259c183c66b
Source dataset
uspto-grants-2011_01
Patent number
US07863285B2

Linked notes

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